The suPAR level is elevated in cancer patients compared to healthy individuals, and a high suPAR level is associated with:

  • Advanced disease
  • High TNM stage
  • Aggressive and invasive tumor growth
  • Metastatic disease
  • Poor prognosis

This applies to various types of cancer, among others:

  • Acute leukemia1
  • Colorectal cancer2–4
  • Hepatic cancer5
  • Cervical cancer6
  • Lung cancer (small cell and non-small cell)7
  • Lymphomas8
  • Ovarian cancer9
  • Pancreatic cancer10
  • Prostate cancer11
  • Esophageal cancer3
  • Gastric cancer3,12

Thus, various cancers cause an elevated plasma suPAR level. The more serious and advanced disease, the higher suPAR level. suPAR is therefore also a prognostic marker in cancer patients reflecting mortality. Cancer patients with a low suPAR level have a better chance of progression-free survival.

In the general population, an elevated suPAR level is associated with an increased risk of lung cancer and other cancers. Among smokers, the risk of lung cancer is also higher in individuals with an elevated suPAR level compared to those with lower suPAR levels13.

In prostate cancer patients, the suPAR level is higher than in patients with benign prostatic hyperplasia11.

In neurologic patients with paraneoplastic cerebellar syndromes or carcinomatous meningitis, the suPAR level is also elevated in plasma and in cerebrospinal fluid14.

In patients with gastrointestinal cancers, the suPAR level is higher in patients with esophageal cancer than in patients with colorectal cancer3.

suPAR in relation to cancer diagnostics and other biomarkers

In patients with liver diseases, an elevated suPAR level has proved to be an early predictor of future development of hepatocellular carcinoma, and the suPAR level may be elevated as early as 1-7 years prior to appearance of imaging signs of hepatic cancer. In this study, suPAR was statistically stronger than alpha-fetoprotein5.

In patients with ovarian tumors, a combination of suPAR and CA-125 is able to discriminate benign tumors from malignant tumors (AUC 0.94; 95% CI 0.90-0.98)9.

suPAR in cancer treatment

In patients in with resectable colorectal cancer, the suPAR level is lower than in patients with unresectable disease receiving palliative treatment3,4. Furthermore, suPAR might help to guide preoperative treatment decisions regarding patients' outcome and to identify patients particularly susceptible to acute kidney injury16.

In women with cervical cancer, the suPAR level decreases significantly following surgery6.

In patients with acute leukemia, the suPAR plasma level correlates with the number of circulating tumor cells, and following treatment with chemotherapy, the suPAR level decreases to a normal level in parallel with a reduction in the number of tumor cells1.

In patients without known cancer but with serious nonspecific symptoms and signs of cancer referred to a diagnostic outpatient clinic for an accelerated cancer diagnostic program, elevated suPAR levels were significantly associated with newly diagnosed cancer during follow-up15. Thus, a high suPAR level is associated with increased risk of finding cancer patients15. In cancer patients, elevated suPAR levels are associated with a poor prognosis and a shorter survival4,10–12.


1. Mustjoki, S., Sidenius, N. & Sier, C. F. M. Soluble Urokinase Receptor Levels Correlate with Number of Circulating Tumor Cells in Acute Myeloid Leukemia and Decrease Rapidly during Chemotherapy Soluble Urokinase Receptor Levels Correlate with Number of Circulating Tumor Cells in Acute Myeloid Leuke. 7126–7132 (2000).
2. Lomholt, a F., Høyer-Hansen, G., Nielsen, H. J. & Christensen, I. J. Intact and cleaved forms of the urokinase receptor enhance discrimination of cancer from non-malignant conditions in patients presenting with symptoms related to colorectal cancer. Br. J. Cancer 101, 992–7 (2009).
3. Usnarska-Zubkiewicz, L., Strutyńska-Karpińska, M., Zubkiewicz-Kucharska, A., Zarębski, P. & Grabowski, K. Soluble Urokinase-Type Plasminogen Activator Receptor and Ferritin Concentration in Patients with Advanced Alimentary Tract Carcinoma. Relationship to Localization, Surgical Treatment and the Stage of the Disease - Preliminary Report. Adv. Clin. Exp. Med. 23, 959–967 (2014).
4. Tarpgaard, L. S. et al. Intact and cleaved plasma soluble urokinase receptor in patients with metastatic colorectal cancer treated with oxaliplatin with or without cetuximab. Int. J. Cancer 1, n/a–n/a (2015).
5. Chounta, A. et al. Serum soluble urokinase plasminogen activator receptor as a screening test for the early diagnosis of hepatocellular carcinoma. Liver Int. 35, 601–607 (2015).
6. Jing, J. et al. Evaluating the value of uPAR of serum and tissue on patients with cervical cancer. J. Clin. Lab. Anal. 26, 16–21 (2012).
7. Cobos, E., Jumper, C. & Lox, C. Pretreatment Determination of the Serum Urokinase Plasminogen Activator and its Soluble Receptor in Advanced Small-Cell Lung Cancer or Non- Small-Cell Lung Cancer. Clin. Appl. Thromb. 9, 241–246 (2003).
8. Rubio-Jurado, B. et al. Circulating Levels of Urokinase-Type Plasminogen Activator Receptor and D-Dimer in Patients With Hematological Malignancies. Clin. Lymphoma Myeloma Leuk. 15, 621–626 (2015).
9. Henic, E., Borgfeldt, C., Christensen, I. J., Casslén, B. & Høyer-Hansen, G. Cleaved forms of the urokinase plasminogen activator receptor in plasma have diagnostic potential and predict postoperative survival in patients with ovarian cancer. Clin. Cancer Res. 14, 5785–93 (2008).
10. Sorio, C. et al. Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group. BMC Cancer 11, 448 (2011).
11. Miyake, H. et al. Elevation of serum levels of urokinase-type plasminogen activator and its receptor is associated with disease progression and prognosis in patients with prostate cancer. Prostate 39, 123–9 (1999).
12. Fidan, E. et al. Diagnostic and prognostic significance of CA IX and suPAR in gastric cancer. Med. Oncol. 30, 540 (2013).
13. Langkilde, A. et al. Increased plasma soluble uPAR level is a risk marker of respiratory cancer in initially cancer-free individuals. Cancer Epidemiol. biomarkers Prev. 20, 609–18 (2011).
14. Garcia-Monco, J. C., Coleman, J. L. & Benach, J. L. Soluble urokinase receptor (uPAR, CD 87) is present in serum and cerebrospinal fluid in patients with neurologic diseases. J. Neuroimmunol. 129, 216–223 (2002).
15. Rasmussen LJH, et al. Inflammatory biomarkers and cancer: CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer. Int J Cancer. 2017 Jul 1;141(1):191-199.
16. Loosen SH et al, Serum levels of soluble urokinase plasminogen activator receptor (suPAR) predict outcome after resection of colorectal liver metastases. Oncotarget. 2018 Jun 5;9(43):27027-27038.