Elevated preoperative suPAR levels is a strong and independent risk marker for postoperative complications in patients undergoing major surgery.
Listen to Jesper Eugen-Olsen, PhD, Senior Scientist at Copenhagen University Hospital Hvidovre and CSO at ViroGates, present the results of the study showing that elevated preoperative suPAR can influence post surgery complications in patients.
More information about the study
Preoperative suPAR provided solid and independent predictive value on postoperative complications in White patients undergoing major noncardiac surgery.
EDTA (Ethylenediaminetetraacetic Acid) blood was collected from adults (≥18 years old). More precisely, White patients who were scheduled for major noncardiac surgery with an expected duration of≥2 hours under general anesthesia. Plasma suPAR levels were determined using the suPARnostic® quick triage lateral flow assay. The primary endpoint was postoperative complications, defined as the presence of any complication and/or admission to the intensive care unit and/or mortality within the first 90 postoperative days.
Preoperative suPAR had an odds ratio of 1.50 for every ng/mL increase. When including age, sex, American Society of Anesthesiologists score, C-reactive protein, and grouped suPAR in multivariate analysis, patients with suPAR levels between 5.5 and 10 ng/mL had an odds ratio of 11.2, and patients with suPAR >10 ng/mL had an odds ratio of 19.9 compared to patients with suPAR ≤5.5 ng/mL, respectively.