Mon Feb 07 2022

Soluble urokinase receptor and mortality in kidney transplant recipients

A recent study by Heidelberg University Hospital explored how well suPAR predicts cardiovascular events and mortality in kidney transplant recipients. Researchers examined the link between suPAR levels measured before or one year post-transplant and outcomes in 1,023 patients.


A high suPAR level before and one year after kidney transplantation increases the risk of patient death, regardless of kidney function, mainly due to cardiovascular causes.


Serum suPAR levels in a total of 1,023 kidney transplant recipients either before (cohort 1, n = 474) or at year 1 after transplantation (cohort 2, n = 549) were measured. The association of suPAR levels and all-cause and cardiovascular mortality was evaluated by multivariable Cox regression analysis.


The highest suPAR tertile compared to the two lower tertiles had a significantly higher risk of all-cause mortality in both cohorts separately (cohort 1: hazard ratio (HR) 1.92, 95% confidence interval (CI) 1.20–3.08, p = 0.007; cohort 2: HR = 2.78, 95% CI 1.51–5.13, p = 0.001) and combined (n = 1,023, combined HR = 2.14, 95% CI 1.48–3.08, p < 0.001). The association remained significant in the subgroup of patients with normal kidney function (cohort 2: HR = 5.40, 95% CI 1.42–20.5, p = 0.013). The increased mortality risk in patients with high suPAR levels was attributable mainly to an increased rate of cardiovascular death (n = 1,023, HR = 4.24, 95% CI 1.81–9.96, p < 0.001).


published suPAR studies in leading medical journals

Nature Medicine Logo
Science Journal Logo
JAMA Pediatrics Logo

The suPARnostic® brand consists of four products:

Quick Triage

Quick Triage

A Point of Care Solution


For Automated Systems


Clinical and Research


Point-of-care finger prick

New Webinar


Catch COVID-19

-Improve your triage

Sign up to view webinar recording

View recording

suPARnostic® by ViroGates