Thu Oct 21 2021

NEW STUDY

suPAR is associated with risk for thromboembolic complications and mortality in patients with COVID-19

Conclusion

Higher suPAR levels at the time of hospital admission are associated with a higher risk for thromboembolic complications i.e., pulmonary embolism (PE) and deep venous thrombosis (DVT), as well as mortality in patients with COVID-19.

new study: suPAR and the risk for thromboembolic complications

Results

Per quartile higher suPAR level, there was a higher risk for PE or DVT. Compared to those in the lowest suPAR quartile, patients in the highest quartile had an 11.1 times higher risk for PE/DVT. suPAR is also associated with overall mortality, with a 2.25 times higher risk of death seen per quartile increase in suPAR level.

Method

This is a retrospective cohort study, conducted by Rush University Medical Center, of a random sample of 109 patients among those hospitalized between March and June 2020 for COVID-19, who had blood samples collected and stored on admission.

Patients were subsequently grouped by suPAR quartiles. Associations between suPAR, thromboembolic complications, and overall mortality were evaluated using multivariable logistic regression.

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published suPAR studies in leading medical journals

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Clinical and Research

suPAR is used in clinical routine in 38 hospitals

38 hospitals use suPAR in clinical routine for triage of patients in the Emergency Departments and COVID-19 units. Clinical routine is defined by the placement of two Purchasing Orders within the last 12 months rolling. This period covers October 1, 2021, until September 30, 2022.
Some hospital locations cannot be disclosed due to confidentiality.

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