Study combining suPAR and NEWS documents significantly improved risk stratification in Acute Medical patients
Wed Oct 03 2018
Combining National Early Warning Score With Soluble Urokinase Plasminogen Activator Receptor (suPAR) Improves Risk Prediction in Acute Medical Patients: A Registry-Based Cohort Study
Data from a large observational study comprising 17,312 patients admitted at the Acute Medical Unit at Copenhagen University Hospital Amager and Hvidovre, Denmark has been published in the highly accredited medical journal Critical Care Medicine.
Results show that combining the National Early Warning Score (NEWS) with suPAR improves risk stratification significantly in acute medical patients.
The study analyzed the effect of measuring suPAR compared to using a conventional triage/risk stratification system (NEWS) that is used in the emergency departments and other acute medical units internationally.
The study concluded that using suPAR in combination with NEWS significantly improved risk prediction of both low- and high-risk acute medical patients, and could potentially lead to clinical interventions among acute medical patients otherwise not considered urgent or at risk, thereby ultimately saving lives.
suPAR was a stronger predictor of mortality in patients without clinical signs of risk of deterioration. Patients with low NEWS but high suPAR levels had mortality risks comparable to that of patients with higher NEWS.
The suPAR level increased with increasing NEWS, and high suPAR independently predicted risk of mortality across NEWS scores, thereby adding prognostic value to the NEWS.