Thu Oct 21 2021

suPAR is associated with risk for thromboembolic complications and mortality in patients with COVID-19


Higher suPAR levels at the time of hospital admission are associated with a higher risk for thromboembolic complications i.e., pulmonary embolism (PE) and deep venous thrombosis (DVT), as well as mortality in patients with COVID-19.

new study: suPAR and the risk for thromboembolic complications


Per quartile higher suPAR level, there was a higher risk for PE or DVT. Compared to those in the lowest suPAR quartile, patients in the highest quartile had an 11.1 times higher risk for PE/DVT. suPAR is also associated with overall mortality, with a 2.25 times higher risk of death seen per quartile increase in suPAR level.


This is a retrospective cohort study, conducted by Rush University Medical Center, of a random sample of 109 patients among those hospitalized between March and June 2020 for COVID-19, who had blood samples collected and stored on admission.

Patients were subsequently grouped by suPAR quartiles. Associations between suPAR, thromboembolic complications, and overall mortality were evaluated using multivariable logistic regression.


published suPAR studies in leading medical journals

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