Wed Aug 18 2021

New study: suPAR (cut-off levels ⩽4, 4-6, and ⩾6 ng/mL) can predict the need for mechanical ventilation and mortality in patients with COVID-19 symptoms.

suPAR is a biomarker associated with adverse outcomes. This study aimed to investigate the associations between plasma suPAR levels (testing the cut-offs ⩽4, 4-6, and ⩾6 ng/mL) with risk of 14-day mortality, and with the risk of mechanical ventilation in patients that tested positive for SARS-CoV-2.

This observational cohort study of 386 patients presenting symptoms of COVID-19 at the Department of Emergency Medicine, Amager and Hvidovre Hospital, Denmark from March 19th, 2020 to April 3rd, 2020, found suPAR levels predictive of mortality and the need for mechanical ventilation.

Validation of the findings was carried out in a similar-sized COVID-19 patient cohort from Mikkeli Central Hospital, Finland.

Conclusions:

Patients with symptoms of COVID-19 and suPAR ⩽4 or ⩾6 ng/mL had low or high risk, respectively, concerning the need for mechanical ventilation or mortality.

Read the full study

Other studies supporting this cut-off

1: Santeri Seppälä, Andreas Peter Andersen, Kristiina Nyyssönen et al. suPAR Cut-offs for Stratification of Low, Medium, and High-risk Acute Medical Patients in the Emergency Department, 26 May 2021, PREPRINT (Version 1) available at Research Square. https://www.researchsquare.com/article/rs-542503/v1
2: Altintas, I., Eugen-Olsen, J., Seppälä, S., Tingleff, J., Stauning, M. A., El Caidi, N. O., Elmajdoubi, S., Gamst-Jensen, H., Lindstrøm, M. B., Rasmussen, L. J. H., Kristiansen, K. T., Rasmussen, C., Nehlin, J. O., Kallemose, T., Hyppölä, H., & Andersen, O. (2021). suPAR Cut-Offs for Risk Stratification in Patients With Symptoms of COVID-19. Biomarker Insights. https://journals.sagepub.com/doi/full/10.1177/11772719211034685 

+700

published suPAR studies in leading medical journals

The suPARnostic® brand consists of 3 products:

Photo of The suPARnostic® Quick Triage kit

Quick Triage

A Point of Care Solution

Photo of suPARnostic® TurbiLatex

TurbiLatex

For Automated Systems

Photo of suPARnostic® ELISA

ELISA Assay

Clinical and Research

Would you like to know more?

If you have any questions regarding our products or business, write to us here

Thank you!

You'll hear from us shortly.

An error occured!

Please try again, or contact us by e-mail if the problem persist.

Sign up for our newsletter

By signing up for our newsletter you will receive the latest news about our products.

Thank you!

You'll hear from us shortly.

An error occured!

Please try again, or contact us by e-mail if the problem persist.

New Webinar

Webinar

Catch COVID-19

-Improve your triage

Sign up to view webinar recording

View recording

suPARnostic® by ViroGates