New study confirms the prognostic role of suPAR with high negative predictive value in the ED

Tue May 12 2020

The Hellenic Sepsis Study Group has confirmed the importance of suPAR as a marker that can reliably rule out conditions, showing that levels below 4 ng/mL support a safe discharge decision following a clinical evaluation. This finding appears in a Position Paper published in Infectious Diseases and Therapy by Velissaris D. et al.

Given the growing evidence of suPAR’s high negative predictive value, experts in intensive care, emergency medicine, internal medicine, and infectious diseases have issued a position statement on suPAR’s use in emergency department patient screening.

This statement highlights suPAR as a non-specific marker with a high negative predictive value for predicting adverse outcomes. It notes that levels below 4 ng/mL generally mean discharge is safe, while levels above 6 ng/mL indicate a significant risk of poor outcomes. Clinicians should consider suPAR levels alongside the patient’s medical history.

The statement underscores the importance of early risk detection in triaging emergency department patients, which can significantly influence their outcomes. It acknowledges the challenges of triage, especially when clinical signs are subtle or non-specific, and proposes suPAR as a tool for early risk identification in such cases.

The following statement regarding the utility of suPAR for patients admitted to the ED was made:

Infectious Diseases and Therapy

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Infect Dis Ther

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