suPAR is a Risk Marker for Kidney Disease in Acute Medical Patients
Fri Jun 12 2020
New study showing that elevated suPAR is an independent risk marker for incident chronic and acute kidney disease in acute medical patients, is published in Frontiers in Cell and Developmental Biology by Iversen E. et al.
The aim of the study was to determine whether elevated plasma suPAR level measured at hospital admission is associated with incident kidney disease in patients presenting to the emergency department.
More than 25.000 acute medical patients were followed for 4 years for development of kidney disease.
Results shows a 57% higher risk of developing a chronic kidney condition and 151% higher risk of developing an acute kidney condition with each doubling in suPAR level at hospital admission.
Thus, elevated suPAR level in acute medical patients is independently associated with incident chronic and acute kidney conditions, as well as all-cause mortality.
This highlights the potential for using suPAR in risk classification models to identify high-risk patients, who could benefit from early clinical interventions.
If patients are classified based of the risk of developing kidney disease, then closer monitoring and early interventions in high risk patients may slow kidney disease progression and avoid complications related to renal dysfunction.