Thu Nov 04 2021

Elevated preoperative suPAR is a strong and independent risk marker for postoperative complications in patients undergoing major noncardiac surgery

A recent study explored if the soluble urokinase plasminogen activator receptor (suPAR) could help identify high-risk patients facing postoperative issues after major noncardiac surgeries in White individuals. The study concluded that checking suPAR levels before surgery significantly predicts postoperative complications.

Researchers collected EDTA blood from adult White patients (18 years or older) set for major noncardiac surgeries expected to last at least two hours under general anesthesia. They used the suPARnostic quick triage lateral flow assay to measure plasma suPAR levels. They aimed to see if there were any postoperative complications, ICU admissions, or deaths within the first 90 days after surgery.

The study found that each ng/mL increase in preoperative suPAR levels raised the odds of postoperative complications by 1.5 times. Further analysis, accounting for factors like age, sex, American Society of Anesthesiologists score, and C-reactive protein levels, showed that patients with suPAR levels between 5.5 and 10 ng/mL were 11.2 times more likely to face complications, and those with levels above 10 ng/mL were 19.9 times more likely, compared to patients with levels at or below 5.5 ng/mL.

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