Prediction of acute kidney injury (AKI) and requirement for dialysis for COVID-19 patients

Wed Jan 20 2021

Soluble Urokinase Receptor (SuPAR) in COVID-19–Related AKI, published in the Journal of the American Society of Nephrology

Patients infected with COVID-19 often develop AKI and many of those patients require dialysis.

In a recent paper, Azam et al investigated the link between a patient’s suPAR level and incidence of in-hospital AKI. It appeared that in patients hospitalized with COVID-19, the suPAR-level at the time of admission was a strong predictor of developing in-hospital AKI and the need for dialysis. The higher the suPAR-level, the more severe the outcome.

The association between suPAR levels and incident in-hospital AKI was examined by measuring suPAR levels in plasma samples from 352 adult patients that had been collected within 48 hours of admission.

For patients admitted with a suPAR-level < 4.60 ng/ml, only a 6.0% incidence of AKI was found with no patients developing a need for dialysis1. For patients admitted with a suPAR level > 6.86 ng/ml, there was a 45.8% incidence of AKI with 16.1% of those patients requiring dialysis1.

The authors concluded that admission suPAR levels in patients hospitalized for COVID-19 are predictive of in-hospital AKI and the need for dialysis. SuPAR may be a key component of the pathophysiology of AKI in COVID-19.

This shows that suPAR can be used to ease the burden of AKI in COVID-19.

Read the article here.

1. Soluble Urokinase Receptor (SuPAR) in COVID-19-Related AKI. Azam TU et al. J Am Soc Nephrol. 2020 (LINK:


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48 hospitals use suPAR in clinical routine for triage of patients in the Emergency Departments and COVID-19 units. Clinical routine is defined by the placement of two Purchasing Orders within the last 12 months rolling.
This period covers January 1, 2022, until December 31, 2022. Some hospital locations cannot be disclosed due to confidentiality.

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