Preoperative suPAR predicts postoperative complications in high-risk patients undergoing major non-cardiac surgery

Tue May 11 2021

Elevated preoperative suPAR is a strong and independent risk marker for postoperative complications in high-risk patients undergoing major non-cardiac surgery

Patients undergoing major surgery are often at risk of developing postoperative complications, which are a common cause of death and morbidity.

These complications also increase admissions to the ICU and hospital length of stay, which impacts healthcare costs.

Preoperative suPAR is a risk marker for postoperative complications in high-risk patients undergoing major non-cardiac surgery

– Chalkias et al., medRxiv, May 2021

The authors of this new study investigated whether the inflammatory biomarker suPAR can aid in identifying patients at high risk for postoperative complications, morbidity, and mortality.

Peripheral venous blood was collected from consecutive adult patients scheduled for major non-cardiac surgery with expected duration ≥2 hours under general anesthesia.

The results show that suPAR can help in identifying patients at high risk for postoperative complications, morbidity, and mortality. For every ng/ml increase, the probability of developing postoperative complications increases by 50%.

The addition of suPAR to other parameters significantly improved the prediction of postoperative complications.

Read the study here

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