Wed Sep 16 2020

Association Between Elevated suPAR

Association Between Elevated suPAR, a New Biomarker of Inflammation, and Accelerated Aging

Methods
We analyzed data from the Dunedin Study, a population-representative birth cohort from New Zealand (n = 1037), born in 1972–1973 and observed until age 45. We measured plasma suPAR levels at ages 38 and 45, conducting regression analyses that accounted for sex, smoking, C-reactive protein, and current health conditions.

Background
To gauge the link between chronic inflammation, aging, and age-related diseases, we need standard biomarkers for systemic chronic inflammation. Our study examined if high blood levels of suPAR, a marker of chronic inflammation, correlate with faster aging, diminished functional capacity, and cognitive decline.

Of the 997 living participants, 875 (88%) had their plasma suPAR measured at age 45. We found that higher suPAR levels were linked to quicker biological aging in multiple organ systems, an older-looking face, and signs of brain aging. Participants with elevated suPAR levels also experienced more significant declines in physical and cognitive function from childhood to adulthood compared to those with lower levels. Additionally, improving health habits between ages 38 and 45 correlated with less significant increases in suPAR levels.

Conclusions
Our results support using suPAR to explore chronic inflammation’s impact on accelerated aging and functional decline.

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