suPAR in the Emergency Department

suPAR is a prognostic tool reflecting the extent of activation of our immune system non-specific to any individual disease.

This is the key advantage: The suPAR-level is, across diseases, directly linked to morbidity and mortality and therefore can be used to discriminate between non-survivors and survivors.

In Acute Triage, this will allow the hospital to:

  • Identify, treat and hospitalize those first who need it most:
    Ill patients with inflammation associated with an increased disease severity, readmission and mortality risk (elevated suPAR-level).
  • Identify those who can be discharged following treatment because their prognosis is good (low suPAR-level), which will
    • Shorten the average patient-length-of-stay
    • Free up beds in the Emergency Department
    • Lead to significant cost savings for the hospital
A drawing of what suPAR is and how it can be used

suPARnostic® Patient Guideline: suPARnostic® improves patient care and reduces healthcare costs by classifying 34% more patients into low-risk category. 1

In the emergency departments, shortened hospital stays and a reduced number of beds cause a large patient turnover.

For optimal treatment and observation of patients admitted to the emergency departments, a proper risk assessment is needed to ensure that the most ill patients are prioritized and are quickly examined and put under a more careful observation.

Studies from various emergency departments located in the Copenhagen region, Denmark, among others the emergency departments at Hvidovre Hospital, Hillerød Hospital, and Frederiksberg Hospital, have shown that suPAR is associated with:

    • Age1,2
    • Severe and/or multiple comorbidities1,2
    • Length of hospital stay2
    • Admission to an intensive care unit2,3
    • Readmission within 30 and 90 days2
    • 48-hour, 30-day and 90-day mortality2

This means that in acute medical patients, suPAR measured on admission is higher in elderly patients, patients who end up being admitted for a long period, patients ending up in the intensive care unit, seriously or chronically ill patients, and multimorbid patients as well as patients who are readmitted or die within 30 as well as 90 days1–4.

Even taking into account other well-known prognostic factors, including sex, age, Charlson score, and CRP, suPAR still remains an independent predictor of readmission and mortality within 30 as well as 90 days2.

Medical staff discussing over medical reports in hospital

On the other hand, patients with a low suPAR level are at a lower risk of being readmitted or dying compared to others of the same age. Example:

      • The background 30- and 90-day mortality in patients below the age of 70 is 1.5% and 2.9%, respectively2.
      • In a patient below the age