The suPAR level is significantly higher in patients with cirrhosis compared to healthy controls1,2. In a study of 159 patients with chronic hepatic diseases, including 98 patients with cirrhosis, the diagnostic ability of suPAR in identifying cirrhosis was good, and suPAR was a strong predictor of mortality or need of transplantation. A cutoff level >9 ng/mL predicted a poor prognosis with a sensitivity and specificity of 70.7% and 77.8%, respectively, as well as a relative risk of 8.5 (3.5-20.3)1.
The suPAR level is higher in patients with alcoholic etiology and correlates positively with fibrosis1,3,4. In addition, the suPAR level is higher in individuals with excessive alcohol consumption compared to healthy individuals3.
In patients with decompensated cirrhosis, the suPAR level is significantly higher (median 12.9 ng/mL) than in patients with compensated cirrhosis (8.9 ng/mL), and suPAR is associated with 28-day mortality5.
In patients with spontaneous bacterial peritonitis, an elevated suPAR level in ascites fluid was found, and the level was associated with severity and prognosis5.