The association between suPAR and chronic renal diseases has been further studied in a large study4. It was found that the suPAR level was an independent predictor of declining eGFR. During the study follow-up period of 3.7 years, the decline in eGFR in subjects in the lower suPAR quartile was 0.9 mL/min/1.73 m2 and 4.2 mL/min/1.73 m2 in the upper quartile.
In 1335 individuals with an eGFR >60 mL/min/1.73 m2 at study start, a suPAR level in the upper quartile was associated with a significantly increased incidence of chronic renal diseases compared to those in the lower quartile; all in all, a 3-fold increased risk4.
In patients with primary and secondary glomerulonephritis, an elevated suPAR level is similarly associated with reduced eGFR and presence of proteinuria5.