By: Ditte Bjerre, ViroGates

In recent months, the World has been fighting the coronavirus SARS-CoV-2 (COVID-19). Per May 1st, 2020, over three million have tested positive for COVID-19 and more than 200,000 have died.1 Scientists worldwide have since the beginning of the COVID-19 crisis collected data from patients infected with the virus in order to understand the pathology better and learn how to fight the disease.

On April 30, a paper was published in Critical Care authored by Rovina and co-authors2 describing that at the beginning of the illness, patients may experience low-degree fever or flu-like symptoms, but suddenly severe respiratory failure (SRF) can emerge3. Other studies further showed increased levels of circulating D-dimers3,4 suggesting endothelial activation. The urokinase Plasminogen Activator Receptor (uPAR), bound on the surface of the endothelium, may be cleaved early during the disease. This leads to an increase of suPAR5, making suPAR an early predictor of the risk of SRF