What is suPAR?

suPAR (soluble uPAR) is a protein in the blood that reflects immune activation. All human beings have a baseline level of suPAR that is individually determined and increases with age.

High suPAR levels are associated with increased inflammation, disease progression, and risk of mortality in acute and chronic diseases, and in the general population3-16. Measuring suPAR levels can thus serve as a marker to determine who can be classified into low-risk category and their chances for survival upon hospital admission. suPAR can also be used for monitoring for prevention of disease progression and earlier intervention time point.

The suPAR level is elevated across diseases, and not solely associated with one specific disease. Therefore, suPAR is applicable as a prognostic marker and not as a diagnostic marker. This characteristic may be utilized for risk stratification in unselected patients.

The suPAR blood level is stable with no diurnal variation and no changes following fasting. It can be measured in blood, plasma, urine, cerebrospinal fluid, ascites fluid, and pleural fluid1. The level increases and decreases with progression and improvement of a disease, respectively.

suPAR in Triage

The normal suPAR plasma level is below 3 ng/mL in healthy individuals, about 3-6 ng/mL in unselected patients in emergency departments, and above 6 ng/mL in critically ill patients.

A low suPAR level indicates a good prognosis and supports the decision to discharge the patient.

A high suPAR level indicates presence, progression and severity of disease, and supports further clinical attention.

A drawing of what suPAR is and how it can be used

suPARnostic® Patient Guideline: suPARnostic® improves patient care and reduces healthcare costs by classifying 34% more patients into low-risk category. 2

The suPAR level can be used for triage in the hospital’s Emergency Department and can be measured using the suPARnostic® products, the only CE-IVD certified product range applied for clinical determination of suPAR.

By using suPARnostic® in the triage process, performance of the ED is significantly improved. suPARnostic®
can identify 22% more patients that can be sent home without hospitalization, and help to avoid unnecessary
treatments and readmissions.2

Figure 1. Schematic representation of urokinase receptor. The GPI-anchor links uPAR to the cell membrane making it available for uPA to bind to the receptor (1 A). When the receptor is cleaved between the GPI-anchor and D3, it becomes soluble (suPAR) (1 B). suPAR is a stable protein that can be measured in various body fluids. uPA: urokinase-type plasminogen activator, uPAR: uPA receptor, suPAR: soluble uPAR, 1: Domain 1, D2: Domain 2, D3: Domain