suPAR (soluble uPAR) is a protein in the blood that reflects immune activation. All human beings have a baseline level of suPAR that is individually determined and increases with age.
High suPAR levels are associated with increased inflammation, disease progression, and risk of mortality in acute and chronic diseases, and in the general population3-16. Measuring suPAR levels can thus serve as a marker to determine who can be classified into low-risk category and their chances for survival upon hospital admission. suPAR can also be used for monitoring for prevention of disease progression and earlier intervention time point.
The suPAR level is elevated across diseases, and not solely associated with one specific disease. Therefore, suPAR is applicable as a prognostic marker and not as a diagnostic marker. This characteristic may be utilized for risk stratification in unselected patients.
The suPAR blood level is stable with no diurnal variation and no changes following fasting. It can be measured in blood, plasma, urine, cerebrospinal fluid, ascites fluid, and pleural fluid1. The level increases and decreases with progression and improvement of a disease, respectively.